Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.
<h4>Background</h4>There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is critical to identifying novel tar...
Main Authors: | Uma V Mahajan, Vijay R Varma, Michael E Griswold, Chad T Blackshear, Yang An, Anup M Oommen, Sudhir Varma, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Timothy J Hohman, Cristina Legido-Quigley, Madhav Thambisetty |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
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Series: | PLoS Medicine |
Online Access: | https://doi.org/10.1371/journal.pmed.1003012 |
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