Recombinant myostatin reduces highly expressed microRNAs in differentiating C2C12 cells

Myostatin is small glycopeptide that is produced and secreted by skeletal muscle. It is a potent negative regulator of muscle growth that has been associated with conditions of frailty. In C2C12 cells, myostatin limits cell differentiation. Myostatin acts through activin receptor IIB, activin recept...

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Bibliographic Details
Main Authors: Zachary A. Graham, Rita De Gasperi, William A. Bauman, Christopher P. Cardozo
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817300110