O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

Abstract Background The homologous recombination (HR) pathway is involved in DNA damage response (DDR), which is crucial to cancer cell survival after treatment with DNA damage agents. O6-methylguanine DNA methyltransferase (MGMT) is associated with cisplatin (CDDP) resistance in cancer cells; howev...

Full description

Bibliographic Details
Main Authors: Shang-Hung Chen, Wen-Tsung Huang, Wan-Chen Kao, Sheng-Yen Hsiao, Hsin-Yi Pan, Chin-Wen Fang, Yow-Ling Shiue, Chia-Lin Chou, Chien-Feng Li
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Biomedical Science
Subjects:
MGMT
Cisplatin
Homologous recombination
PARP inhibitor
Nasopharyngeal carcinoma
Online Access:https://doi.org/10.1186/s12929-020-00699-y

Internet

https://doi.org/10.1186/s12929-020-00699-y

Similar Items