MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Summary: Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate and pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1). Recent studies suggest that loss of OL MCT1 causes axonal degeneration. However, it is unknown how widesp...

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Bibliographic Details
Main Authors: Thomas Philips, Yevgeniya A. Mironova, Yan Jouroukhin, Jeannie Chew, Svetlana Vidensky, Mohamed H. Farah, Mikhail V. Pletnikov, Dwight E. Bergles, Brett M. Morrison, Jeffrey D. Rothstein
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
oligodendrocyte
monocarboxylate transporter 1
lactate
pyruvate
metabolic support
neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720315990

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http://www.sciencedirect.com/science/article/pii/S2211124720315990

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