Site‐Specific Load‐Induced Expansion of Sca‐1+Prrx1+ and Sca‐1−Prrx1+ Cells in Adult Mouse Long Bone Is Attenuated With Age

Site‐Specific Load‐Induced Expansion of Sca‐1+Prrx1+ and Sca‐1−Prrx1+ Cells in Adult Mouse Long Bone Is Attenuated With Age

ABSTRACT Aging is associated with significant bone loss and increased fracture risk, which has been attributed to a diminished response to anabolic mechanical loading. In adults, skeletal progenitors proliferate and differentiate into bone‐forming osteoblasts in response to increasing mechanical sti...

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Bibliographic Details
Main Authors: Pamela Cabahug‐Zuckerman, Chao Liu, Cinyee Cai, Ian Mahaffey, Stephanie C Norman, Whitney Cole, Alesha B Castillo
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:JBMR Plus
Subjects:
LOAD‐INDUCED BONE FORMATION
AGING
OSTEOGENESIS
SKELETAL STEM CELL
PRRX1
Online Access:https://doi.org/10.1002/jbm4.10199

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