Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis

Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis

We specify the clinical features of a spontaneous experimental autoimmune uveitis (EAU) model, in which foreign hen-egg lysozyme (HEL) is expressed in the retina, controlled by the promoter for interphotoreceptor retinol binding protein (IRBP). We previously reported 100% P21 (post-partum day) IRBP:...

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Bibliographic Details
Main Authors: Yi-Hsia Liu, Christine Mölzer, Kimmo Makinen, Koju Kamoi, Clare L. C. Corbett, Izabela P. Klaska, Delyth M. Reid, Heather M. Wilson, Lucia Kuffová, Richard J. Cornall, John V. Forrester
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
autoimmune uveitis
cell therapy
adoptive transfer
hen-egg lysozyme
T cell anergy
anti-uveitogenic
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02071/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.02071/full

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