Liraglutide via Activation of AMP-Activated Protein Kinase-Hypoxia Inducible Factor-1α-Heme Oxygenase-1 Signaling Promotes Wound Healing by Preventing Endothelial Dysfunction in Diabetic Mice

Liraglutide via Activation of AMP-Activated Protein Kinase-Hypoxia Inducible Factor-1α-Heme Oxygenase-1 Signaling Promotes Wound Healing by Preventing Endothelial Dysfunction in Diabetic Mice

Background/Aims: Diabetic foot ulcers (DFUs) present a major challenge in clinical practice, and hyperglycemia-induced angiogenesis disturbance and endothelial dysfunction likely exacerbate DFUs. The long-acting glucagon-like peptide-1 (GLP-1) analog liraglutide (Lira) is a potential activator of AM...

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Bibliographic Details
Main Authors: Huiya Huang, Linlin Wang, Fanyu Qian, Xiong Chen, Haiping Zhu, Mei Yang, Chunxiang Zhang, Maoping Chu, Xiaorong Wang, Xiaozhong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
Liraglutide
diabetic wound healing
endothelial dysfunction
Heme oxygenase-1
5'-AMP activated kinase
hypoxia inducible factor-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.660263/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.660263/full

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