Model-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose Optimization.

Model-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose Optimization.

6-Mercaptopurine (6-MP) is one of the key drugs in the treatment of many pediatric cancers, auto immune diseases and inflammatory bowel disease. 6-MP is a prodrug, converted to an active metabolite 6-thioguanine nucleotide (6-TGN) through enzymatic reaction involving thiopurine methyltransferase (TP...

Full description

Bibliographic Details
Main Authors: Devaraj Jayachandran, José Laínez-Aguirre, Ann Rundell, Terry Vik, Robert Hannemann, Gintaras Reklaitis, Doraiswami Ramkrishna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4520687?pdf=render

Internet

http://europepmc.org/articles/PMC4520687?pdf=render

Similar Items