A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses

A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses

Despite the various roles of type I interferon (type I IFN) responses during bacterial infection, its specific effects in vivo have been poorly characterized in scrub typhus caused by Orientia tsutsugamushi infection. Here, we show that type I IFNs are primarily induced via intracellular nucleic aci...

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Bibliographic Details
Main Authors: Chan-Ki Min, Hong-II Kim, Na-Young Ha, Yuri Kim, Eun-Kyung Kwon, Nguyen Thi Hai Yen, Je-In Youn, Yoon Kyung Jeon, Kyung-Soo Inn, Myung-Sik Choi, Nam-Hyuk Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
scrub typhus
Orientia tsutsugamushi
type I interferon
IL-10
T cells
memory response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02022/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02022/full

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