Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition a...

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Bibliographic Details
Main Authors: Muhammad Zaeem Noman, Jerome Paggetti, Etienne Moussay, Guy Berchem, Bassam Janji
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:OncoImmunology
Subjects:
autophagy
beclin1
cancer immunotherapy
ccl5 cytokine
immune infiltration
immunotherapy
melanoma
natural killer cells
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1452583

Internet

http://dx.doi.org/10.1080/2162402X.2018.1452583

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