Global translational impacts of the loss of the tRNA modification t6A in yeast

Global translational impacts of the loss of the tRNA modification t6A in yeast

The universal tRNA modification t6A is found at position 37 of nearly all tRNAs decoding ANN codons. The absence of t6A37 leads to severe growth defects in baker’s yeast, phenotypes similar to those caused by defects in mcm5s2U34 synthesis. Mutants in mcm5s2U34 can be suppressed by overexpression of...

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Bibliographic Details
Main Authors: Patrick C. Thiaville, Rachel Legendre, Diego Rojas-Benítez, Agnès Baudin-Baillieu, Isabelle Hatin, Guilhem Chalancon, Alvaro Glavic, Olivier Namy, Valérie de Crécy-Lagard
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-12-01
Series:Microbial Cell
Subjects:
t6A
tRNA
ribosome profiling
translation
modified nucleosides
Online Access:http://microbialcell.com/researcharticles/global-translational-impacts-of-the-loss-of-the-trna-modification-t6a-in-yeast/

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http://microbialcell.com/researcharticles/global-translational-impacts-of-the-loss-of-the-trna-modification-t6a-in-yeast/

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