SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player

SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player

Interleukin-1β (IL-1β) is a potent, pro-inflammatory cytokine of the innate immune system that plays an essential role in host defense against infection. However, elevated circulating levels of IL-1β can cause life-threatening systemic inflammation. Hence, mechanisms controlling IL-1β maturation and...

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Bibliographic Details
Main Authors: Anna Zakrzewicz, Katrin Richter, Dariusz Zakrzewicz, Kathrin Siebers, Jelena Damm, Alisa Agné, Andreas Hecker, J. Michael McIntosh, Walee Chamulitrat, Gabriela Krasteva-Christ, Ivan Manzini, Ritva Tikkanen, Winfried Padberg, Sabina Janciauskiene, Veronika Grau
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
annexin II
calcium-independent phospholipase A2β
caspase-1
IL-1β
inflammasome
SLPI
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00664/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00664/full

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