CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis

CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis

Spermatozoa are flagellated cells whose role in fertilization is dependent on their ability to move towards an oocyte. The structure of the sperm flagella is highly conserved across species, and much of what is known about this structure is derived from studies utilizing animal models. One group of...

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Bibliographic Details
Main Authors: Samantha A. M. Young, Haruhiko Miyata, Yuhkoh Satouh, Hirotaka Kato, Kaori Nozawa, Ayako Isotani, R. John Aitken, Mark A. Baker, Masahito Ikawa
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:International Journal of Molecular Sciences
Subjects:
genome editing
targeted mutagenesis
spermatogenesis
sperm motility
Online Access:http://www.mdpi.com/1422-0067/16/10/24732

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http://www.mdpi.com/1422-0067/16/10/24732

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