Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia.

Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia.

Lengthy use of general anesthetics (GAs) causes neurobehavioral deficits in the developing brain, which has raised significant clinical concerns such that the United States Food and Drug Administration (FDA) is warning on the use of GAs in children younger than 3 years. However, the molecular and ce...

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Bibliographic Details
Main Authors: Bin Zhou, Lingmin Chen, Ping Liao, Lu Huang, Zhuo Chen, Daqing Liao, Linghui Yang, Jing Wang, Guoqiang Yu, Li Wang, Jianguo Zhang, Yunxia Zuo, Jin Liu, Ruotian Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000086

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https://doi.org/10.1371/journal.pbio.3000086

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