Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

Abstract Background In menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the critical role in neovascularization and tumorigenesis in breast and other...

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Bibliographic Details
Main Authors: Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati, Sushanta K. Banerjee
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Cancer
Subjects:
Leptin
CCN5
Breast cancer
Proliferation
Invasion and migration
Online Access:http://link.springer.com/article/10.1186/s12885-018-3993-6

Internet

http://link.springer.com/article/10.1186/s12885-018-3993-6

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