Renoprotective Effect of the Histone Deacetylase Inhibitor CG200745 in DOCA-Salt Hypertensive Rats

Renoprotective Effect of the Histone Deacetylase Inhibitor CG200745 in DOCA-Salt Hypertensive Rats

The novel histone deacetylase inhibitor CG200745 was initially developed to treat various hematological and solid cancers. We investigated the molecular mechanisms associated with the renoprotective effects of CG200745 using deoxycorticosterone acetate (DOCA)-salt hypertensive (DSH) rats. DOCA strip...

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Bibliographic Details
Main Authors: Eun Hui Bae, In Jin Kim, Ji Hong Song, Hong Sang Choi, Chang Seong Kim, Gwang Hyeon Eom, Inkyeom Kim, Hyunju Cha, Joong Myung Cho, Seong Kwon Ma, Soo Wan Kim
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
CG200745
HDAC inhibitor
DOCA
hypertension
fibrosis
inflammation
Online Access:https://www.mdpi.com/1422-0067/20/3/508

Internet

https://www.mdpi.com/1422-0067/20/3/508

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