A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature

A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature

Abstract The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug interaction (DDI) studies. High-throughput screening (HTS) assays are commonly used tools to examine...

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Bibliographic Details
Main Authors: Johannes Hochleitner, Muhammad Akram, Martina Ueberall, Rohan A. Davis, Birgit Waltenberger, Hermann Stuppner, Sonja Sturm, Florian Ueberall, Johanna M. Gostner, Daniela Schuster
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08404-0

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https://doi.org/10.1038/s41598-017-08404-0

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