Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in <i>E. coli</i> Pneumosepsis

Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in <i>E. coli</i> Pneumosepsis

Enhancing the immunomodulatory effects of mesenchymal stromal cells (MSCs) may increase their effects in sepsis. We tested the potential for overexpression of Interleukin-10 (IL-10) in human umbilical cord (UC) MSCs to increase MSC efficacy in <i>Escherichia coli</i> (<i>E. coli<...

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Bibliographic Details
Main Authors: Mirjana Jerkic, Claire Masterson, Lindsay Ormesher, Stéphane Gagnon, Sakshi Goyal, Razieh Rabani, Gail Otulakowski, Haibo Zhang, Brian P. Kavanagh, John G. Laffey
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Journal of Clinical Medicine
Subjects:
mesenchymal stromal cell
pneumonia
sepsis
macrophage
phagocytosis
Online Access:https://www.mdpi.com/2077-0383/8/6/847

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https://www.mdpi.com/2077-0383/8/6/847

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