Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

Somatic cell nuclear transfer has established that the oocyte contains maternal factors with epigenetic reprogramming capacity. Yet the identity and function of these maternal factors during the gamete to embryo transition remains poorly understood. In C. elegans, LSD1/KDM1A enables this transition...

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Bibliographic Details
Main Authors: Jadiel A Wasson, Ashley K Simon, Dexter A Myrick, Gernot Wolf, Shawn Driscoll, Samuel L Pfaff, Todd S Macfarlan, David J Katz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
epigenetics
MZT
KDM1a
maternal effect
LSD1
genomic imprinting
Online Access:https://elifesciences.org/articles/08848

Internet

https://elifesciences.org/articles/08848

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