High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to...

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Bibliographic Details
Main Authors: Douglas Maya Miles, Xenia Peñate, Trinidad Sanmartín Olmo, Frederic Jourquin, Maria Cruz Muñoz Centeno, Manuel Mendoza, Marie-Noelle Simon, Sebastian Chavez, Vincent Geli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
histones
chromosomes
Online Access:https://elifesciences.org/articles/35337

Internet

https://elifesciences.org/articles/35337

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