A Multimodal Imaging Approach Demonstrates Reduced Midbrain Functional Network Connectivity Is Associated With Freezing of Gait in Parkinson's Disease

A Multimodal Imaging Approach Demonstrates Reduced Midbrain Functional Network Connectivity Is Associated With Freezing of Gait in Parkinson's Disease

Background: The pathophysiological mechanisms underlying freezing of gait (FOG) are poorly defined. MRI studies in FOG showed a distinct pattern of cortical atrophy and decreased functional connectivity (FC) within motor and cognitive networks. Furthermore, reduced rs-FC within midbrain, frontal, an...

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Bibliographic Details
Main Authors: Amgad Droby, Elisa Pelosin, Martina Putzolu, Giulia Bommarito, Roberta Marchese, Luca Mazzella, Laura Avanzino, Matilde Inglese
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neurology
Subjects:
freezing of gait
functional connectivity
resting-state fMRI
Parkinson's disease
gait analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.583593/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.583593/full

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