Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

Scope: The hypothalamus is a key brain region involved in the control of feeding and energy expenditure. Hypothalamic inflammation and oxidative stress are landmarks of both obesity and aging processes, although the molecular mechanisms are still unknown. Therefore, with the aim to understand the ne...

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Bibliographic Details
Main Authors: Gina Cavaliere, Emanuela Viggiano, Giovanna Trinchese, Chiara De Filippo, Antonietta Messina, Vincenzo Monda, Anna Valenzano, Raffaele I. Cincione, Christian Zammit, Fabiano Cimmino, Angela Catapano, Francesco Sessa, Giovanni Messina, Marcellino Monda, Marianna Crispino, Maria Pina Mollica
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
age
obesity
hypothalamic oxidative stress
inflammation
AMPK activation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00818/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00818/full

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