Poloxamer 407-induced atherosclerosis in mice appears to be due to lipid derangements and not due to its direct effects on endothelial cells and macrophages

Poloxamer 407-induced atherosclerosis in mice appears to be due to lipid derangements and not due to its direct effects on endothelial cells and macrophages

Coronary heart disease secondary to atherosclerosis is still the leading cause of death in the US. Animal models used for elucidating the pathogenesis of this disease primarily involve rabbits and pigs. Previous studies from this laboratory have demonstrated intraperitoneal injections of poloxamer 4...

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Bibliographic Details
Main Authors: Thomas P. Johnston, Yuai Li, Ahmed S. Jamal, Daniel J. Stechschulte, Kottarappat N. Dileepan
Format: Article
Language:English
Published: Hindawi Limited 2003-01-01
Series:Mediators of Inflammation
Subjects:
Atherosclerosis
Inflammation
Interleukins
Lipid oxidation
Low-density lipoprotein
Nitric oxide.
Online Access:http://dx.doi.org/10.1080/0962935031000134860

Internet

http://dx.doi.org/10.1080/0962935031000134860

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