A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals

A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals

Background: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) reverses fibrosis of gut tissue, and whether this le...

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Bibliographic Details
Main Authors: Leslie Renee Cockerham, Steven A. Yukl, Kara Harvill, Ma Somsouk, Sunil K. Joshi, Elizabeth Sinclair, Teri Liegler, Rebecca Hoh, Sophie Lyons, Peter W. Hunt, Adam Rupert, Irini Sereti, David R. Morcock, Ajantha Rhodes, Claire Emson, Marc K. Hellerstein, Jacob D. Estes, Sharon Lewin, Steven G. Deeks, Hiroyu Hatano
Format: Article
Language:English
Published: Case Western Reserve University 2017-08-01
Series:Pathogens and Immunity
Subjects:
Anti-Inflammatory Agents/therapeutic use
CD4 Lymphocyte Count
Disease Reservoirs/*virology
HIV
Immunology
Lymphoid fibrosis
T-cell activation
Online Access:http://paijournal.com/index.php/paijournal/article/view/207

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http://paijournal.com/index.php/paijournal/article/view/207

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