RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion

RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion

Successful adhesion of circulating tumor cells (CTCs) to microvascular endothelium of distant metastatic tissue is the key starting step of metastatic cascade that could be effectively chemoprevented as we demonstrated previously. Here, we hypothesize that the hetero-adhesion may produce secretory b...

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Bibliographic Details
Main Authors: Suhong Yu, Cuicui Yan, Wenjing Wu, Sudan He, Min Liu, Jian Liu, Xingtian Yang, Ji Ma, Yusheng Lu, Lee Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
MDA-MB-231/HPMEC co-culture
metapristone
CYR61
integrin αvβ1
metastasis chemoprevention
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01296/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01296/full

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