Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
Bone development and vascularization are coupled events that share many molecular mechanisms. Here the authors identify osteoblast-secreted Cxcl9 as an inhibitory regulator of angiogenesis and osteogenesis, and show that mTORC1 signaling and STAT1 are critical upstream mediators of the cytokine expr...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms13885 |