Simulating Heterogeneous Tumor Cell Populations.

Certain tumor phenomena, like metabolic heterogeneity and local stable regions of chronic hypoxia, signify a tumor's resistance to therapy. Although recent research has shed light on the intracellular mechanisms of cancer metabolic reprogramming, little is known about how tumors become metaboli...

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Bibliographic Details
Main Authors: Andrew Sundstrom, Dafna Bar-Sagi, Bud Mishra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5193460?pdf=render