Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis

Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis

The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of experime...

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Bibliographic Details
Main Authors: Carolina Prado, Michela Gaiazzi, Hugo González, Valentina Ugalde, Alicia Figueroa, Francisco J. Osorio-Barrios, Ernesto López, Alvaro Lladser, Emanuela Rasini, Franca Marino, Mauro Zaffaroni, Marco Cosentino, Rodrigo Pacheco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
experimental autoimmune encephalomyelitis
antigen-presenting cells
CD4+ T cells
dopamine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00571/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00571/full

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