Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD8+ T cell immunity. To understand the impact of pr...

Full description

Bibliographic Details
Main Authors: Alison J. Carey, Jennifer L. Hope, Yvonne M. Mueller, Adam J. Fike, Ogan K. Kumova, David B. H. van Zessen, Eric A. P. Steegers, Mirjam van der Burg, Peter D. Katsikis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
preterm
neonate
T-cell receptor repertoire
convergent recombination
public clonotypes
diversity analysis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01859/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01859/full

Similar Items