De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.

De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.

We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis. We find that de novo GTP biosynthesis, but not the alternate salvage pathway, is critical to cryptococcal di...

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Bibliographic Details
Main Authors: Carl A Morrow, Eugene Valkov, Anna Stamp, Eve W L Chow, I Russel Lee, Ania Wronski, Simon J Williams, Justine M Hill, Julianne T Djordjevic, Ulrike Kappler, Bostjan Kobe, James A Fraser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3469657?pdf=render

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http://europepmc.org/articles/PMC3469657?pdf=render

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