Vaccination to conserved influenza antigens in mice using a novel Simian adenovirus vector, PanAd3, derived from the bonobo Pan paniscus.

Vaccination to conserved influenza antigens in mice using a novel Simian adenovirus vector, PanAd3, derived from the bonobo Pan paniscus.

Among approximately 1000 adenoviruses from chimpanzees and bonobos studied recently, the Pan Adenovirus type 3 (PanAd3, isolated from a bonobo, Pan paniscus) has one of the best profiles for a vaccine vector, combining potent transgene immunogenicity with minimal pre-existing immunity in the human p...

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Bibliographic Details
Main Authors: Alessandra Vitelli, Mary R Quirion, Chia-Yun Lo, Julia A Misplon, Agnieszka K Grabowska, Angiolo Pierantoni, Virginia Ammendola, Graeme E Price, Mark R Soboleski, Riccardo Cortese, Stefano Colloca, Alfredo Nicosia, Suzanne L Epstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3594242?pdf=render

Internet

http://europepmc.org/articles/PMC3594242?pdf=render

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