Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein

At the end of 2019, a new highly virulent coronavirus known under the name SARS-CoV-2 emerged as a human pathogen. One key feature of SARS-CoV-2 is the presence of an enigmatic insertion in the spike glycoprotein gene representing a novel multibasic S1/S2 protease cleavage site. The proteolytic clea...

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Bibliographic Details
Main Authors: Thomas Lemmin, David Kalbermatter, Daniel Harder, Philippe Plattet, Dimitrios Fotiadis
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Structural Biology: X
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152420300209