Local and abscopal responses in advanced intrahepatic cholangiocarcinoma with low TMB, MSS, pMMR and negative PD-L1 expression following combined therapy of SBRT with PD-1 blockade

Local and abscopal responses in advanced intrahepatic cholangiocarcinoma with low TMB, MSS, pMMR and negative PD-L1 expression following combined therapy of SBRT with PD-1 blockade

Abstract Background Late-stage or recurrent intrahepatic cholangiocarcinoma (ICC) patients exhibit poor prognosis due to limited sensitivity to chemotherapy or radiotherapy and coexistence of multiple lesions. Programmed cell death protein 1 (PD-1) blockade provides a therapeutic opportunity for pat...

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Bibliographic Details
Main Authors: Xiaoliang Liu, Jianfei Yao, Lele Song, Sujing Zhang, Tanxiao Huang, Yu Li
Format: Article
Language:English
Published: BMJ Publishing Group 2019-08-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Intrahepatic cholangiocarcinoma
Radiotherapy
Immunotherapy
PD-1
PD-L1
TMB
Online Access:http://link.springer.com/article/10.1186/s40425-019-0692-z

Internet

http://link.springer.com/article/10.1186/s40425-019-0692-z

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