GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome

GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability. FXS is caused by functional loss of the Fragile X Protein (FXP), also known as Fragile X Mental Retardation Protein (FMRP). In humans and animal models, loss of FXP leads to sensory hypersensitivity, increased su...

Full description

Bibliographic Details
Main Authors: Tori L. Schaefer, Amy A. Ashworth, Durgesh Tiwari, Madison P. Tomasek, Emma V. Parkins, Angela R. White, Andrew Snider, Matthew H. Davenport, Lindsay M. Grainger, Robert A. Becker, Chandler K. Robinson, Rishav Mukherjee, Michael T. Williams, Jay R. Gibson, Kimberly M. Huber, Christina Gross, Craig A. Erickson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Psychiatry
Subjects:
Fragile X syndrome
FXS
FMRP
GABA
EEG
audiogenic seizures
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.678090/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.678090/full

Similar Items