Decreased endomorphin-2 and opioidreceptor in the spinal cord are associated with painful diabetic neuropathy

Decreased endomorphin-2 and opioidreceptor in the spinal cord are associated with painful diabetic neuropathy

Painful diabetic neuropathy (PDN) is one of the most common complications in the early stage of diabetes mellitus (DM). Endomorphin-2 (EM2) selectively activates the opioid receptor (MOR) and subsequently induces antinociceptive effects in the spinal dorsal horn. However, the effects of EM2-MOR in...

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Bibliographic Details
Main Authors: Zhen-Zhen Kou, Fa-Ping Wan, Yang Bai, Chun-Yu Li, Jia-Chen Hu, Guo-Tao Zhang, Zhang Ting, Tao Chen, Ya-Yun Wang, Hui Li, Yun-Qing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Rats, Sprague-Dawley
Painful Diabetic neuropathy
endomorphin 2
spinal dorsal horn;
opioid receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00080/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00080/full

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