Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts: A Next-Generation Sequencing and Bioinformatics Study

Gene Expression Changes Associated with Nintedanib Treatment in Idiopathic Pulmonary Fibrosis Fibroblasts: A Next-Generation Sequencing and Bioinformatics Study

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal interstitial lung disease. Therapeutic options for IPF remain limited. Nintedanib, a tyrosine kinase inhibitor approved for IPF treatment, is known to inhibit fibroblasts proliferation, migration and transformation to myofibrob...

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Bibliographic Details
Main Authors: Chau-Chyun Sheu, Wei-An Chang, Ming-Ju Tsai, Ssu-Hui Liao, Inn-Wen Chong, Po-Lin Kuo
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Journal of Clinical Medicine
Subjects:
bioinformatics
fibroblasts
DDX11
E2F1
idiopathic pulmonary fibrosis
microRNA
mRNA
next-generation sequencing
nintedanib
PLXNA4
Online Access:http://www.mdpi.com/2077-0383/8/3/308

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http://www.mdpi.com/2077-0383/8/3/308

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