EAGLE: Explicit Alternative Genome Likelihood Evaluator

EAGLE: Explicit Alternative Genome Likelihood Evaluator

Abstract Background Reliable detection of genome variations, especially insertions and deletions (indels), from single sample DNA sequencing data remains challenging, partially due to the inherent uncertainty involved in aligning sequencing reads to the reference genome. In practice a variety of ad...

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Bibliographic Details
Main Authors: Tony Kuo, Martin C. Frith, Jun Sese, Paul Horton
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Medical Genomics
Subjects:
Next generation sequencing data analysis
Variant calling
Variant quality score
Genomic variants
Generative probabilistic models
Online Access:http://link.springer.com/article/10.1186/s12920-018-0342-1

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http://link.springer.com/article/10.1186/s12920-018-0342-1

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