Insights into the evolution and emergence of a novel infectious disease.

Many zoonotic, novel infectious diseases in humans appear as sporadic infections with spatially and temporally restricted outbreaks, as seen with influenza A(H5N1). Adaptation is often a key factor for successfully establishing sustained human-to-human transmission. Here we use simple mathematical m...

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Bibliographic Details
Main Authors: Ruben J Kubiak, Nimalan Arinaminpathy, Angela R McLean
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2947978?pdf=render