Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils

Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils

Mild modification of intravenous immunoglobulin (IVIG) has been reported to result in enhanced polyspecificity and leveraged therapeutic effects in animal models of inflammation. Here, we observed that IVIG modification by ferrous ions, heme or low pH exposure, shifted the repertoires of specificiti...

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Bibliographic Details
Main Authors: Stefanie Graeter, Christoph Schneider, Daniëlle Verschoor, Sandro von Däniken, Frank Seibold, Nikhil Yawalkar, Peter Villiger, Jordan D. Dimitrov, David F. Smith, Richard D. Cummings, Hans-Uwe Simon, Tchavdar Vassilev, Stephan von Gunten
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
neutrophil
modified IVIG
cell death
FAS
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00973/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00973/full

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