Implications of non-uniqueness in phylogenetic deconvolution of bulk DNA samples of tumors
Abstract Background Tumors exhibit extensive intra-tumor heterogeneity, the presence of groups of cellular populations with distinct sets of somatic mutations. This heterogeneity is the result of an evolutionary process, described by a phylogenetic tree. In addition to enabling clinicians to devise...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-09-01
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| Series: | Algorithms for Molecular Biology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13015-019-0155-6 |