A case report of EGFR mutant lung adenocarcinoma that acquired resistance to EGFR-tyrosine kinase inhibitors with T790M mutation and epithelial-to-mesenchymal transition

Although a secondary mutation and the epithelial-to-mesenchymal transition (EMT) are encountered very often in patients received the EGFR-TKI targeted treatment. The entire detrimental morphological change of the cancer entity was rare reported. Herein we report a case that acquired resistance to EG...

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Bibliographic Details
Main Authors:	Nana Zhang, Depu Wang, Xiaofeng Li, Zhe Yang, Guanjun Zhang, Yili Wang, Chunbao Wang
Format:	Article
Language:	English
Published:	Elsevier 2017-01-01
Series:	Respiratory Medicine Case Reports
Subjects:	Epidermal growth factor receptor tyrosine kinase inhibitor EGFR-TKI resistance Secondary mutation Epithelial-to-mesenchymal transition
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213007117301788

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http://www.sciencedirect.com/science/article/pii/S2213007117301788

A case report of EGFR mutant lung adenocarcinoma that acquired resistance to EGFR-tyrosine kinase inhibitors with T790M mutation and epithelial-to-mesenchymal transition

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