Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.

Lampe1: an ENU-germline mutation causing spontaneous hepatosteatosis identified through targeted exon-enrichment and next-generation sequencing.

Using a small scale ENU mutagenesis approach we identified a recessive germline mutant, designated Lampe1 that exhibited growth retardation and spontaneous hepatosteatosis. Low resolution mapping based on 20 intercrossed Lampe1 mice revealed linkage to a ∼14 Mb interval on the distal site of chromos...

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Bibliographic Details
Main Authors: Rachel Sheridan, Kristin Lampe, Shiva Kumar Shanmukhappa, Patrick Putnam, Mehdi Keddache, Senad Divanovic, Jorge Bezerra, Kasper Hoebe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3131302?pdf=render

Internet

http://europepmc.org/articles/PMC3131302?pdf=render

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