A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models

A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models

Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivativ...

Full description

Bibliographic Details
Main Authors: Mahesh Chandra Patra, Asma Achek, Gi-Young Kim, Suresh Panneerselvam, Hyeon-Jun Shin, Wook-Yong Baek, Wang Hee Lee, June Sung, Uisuk Jeong, Eun-Young Cho, Wook Kim, Eunha Kim, Chang-Hee Suh, Sangdun Choi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
Toll-like receptor
endosomal TLR
antagonist
QSAR
TAC5
autoimmune diseases
Online Access:https://www.mdpi.com/2073-4409/9/7/1648

Internet

https://www.mdpi.com/2073-4409/9/7/1648

Similar Items