Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.

Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.

Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death. Expression of intracellular serine protease inhibitors (serpins) is one of...

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Bibliographic Details
Main Authors: Pieter J A de Koning, J Alain Kummer, Stefanie A H de Poot, Razi Quadir, Roel Broekhuizen, Anne F McGettrick, Wayne J Higgins, Bart Devreese, D Margaret Worrall, Niels Bovenschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3152296?pdf=render

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http://europepmc.org/articles/PMC3152296?pdf=render

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