A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats

A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats

An elevated level of endoplasmic reticulum (ER) stress is considered an aggravating factor for inflammatory bowel disease (IBD). To develop an ER-stress attenuator that is effective against colitis, 4-phenylbutyric acid (4-PBA), a chemical chaperone that alleviates ER stress, was conjugated with aci...

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Bibliographic Details
Main Authors: Soojin Kim, Seunghyun Lee, Hanju Lee, Sanghyun Ju, Sohee Park, Doyoung Kwon, Jin-Wook Yoo, In-Soo Yoon, Do Sik Min, Young-Suk Jung, Yunjin Jung
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
4-phenylbutyric acid
colon-targeted drug delivery
colitis
prodrug
endoplasmic reticulum stress
chemical chaperone
Online Access:https://www.mdpi.com/1999-4923/12/9/843

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https://www.mdpi.com/1999-4923/12/9/843

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