Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.

Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction.

Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia; however, it is not known whether C4 plays a causative role in this brain disorder. Using confocal imaging and whole-cel...

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Bibliographic Details
Main Authors: Ashley L Comer, Tushare Jinadasa, Balaji Sriram, Rhushikesh A Phadke, Lisa N Kretsge, Thanh P H Nguyen, Giovanna Antognetti, James P Gilbert, Jungjoon Lee, Elena R Newmark, Frances S Hausmann, SaraAnn Rosenthal, Kevin Liu Kot, Yenyu Liu, William W Yen, Borislav Dejanovic, Alberto Cruz-Martín
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000604

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https://doi.org/10.1371/journal.pbio.3000604

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