4-IBP, a σ1 Receptor Agonist, Decreases the Migration of Human Cancer Cells, Including Glioblastoma Cells, In Vitro and Sensitizes Them In Vitro and In Vivo to Cytotoxic Insults of Proapoptotic and Proautophagic Drugs

4-IBP, a σ1 Receptor Agonist, Decreases the Migration of Human Cancer Cells, Including Glioblastoma Cells, In Vitro and Sensitizes Them In Vitro and In Vivo to Cytotoxic Insults of Proapoptotic and Proautophagic Drugs

Although the molecular function of cr receptors has not been fully defined and the natural ligand(s) is still not known, there is increasing evidence that these receptors and their ligands might play a significant role in cancer biology. 4-(N-tibenzylpiperidin-4-yl)-4iodobenzamide (4-IBP), a select...

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Bibliographic Details
Main Authors: Veronique Mégalizzi, Véronique Mathieu, Tatjana Mijatovic, Philippe Gailly, Olivier Debeir, Nancy De Neve, Marc Van Damme, Gianluca Bontempi, Benjamin Haibe-Kains, Christine Decaestecker, Yasuko Kondo, Robert Kiss, Florence Lefranc
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Cancer cell migration
a receptor
Rho GDI
glucosylceramide synthase
orthotopic xenografts
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800868

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http://www.sciencedirect.com/science/article/pii/S1476558607800868

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