Headgroup modification of cholesterol-based cationic lipids: Synthesis, transfection efficiency evaluation, and serum compatibility

Headgroup modification of cholesterol-based cationic lipids: Synthesis, transfection efficiency evaluation, and serum compatibility

There were two objectives for this study. First, it focused on eight lipids having cholesterol as hydrophobic tails, carbamate linkers, and different polar headgroups. Second, it aimed to study the physicochemical properties of those eight lipids, including DNA binding, size, zeta potential, and t...

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Bibliographic Details
Main Authors: Chopaka Thongbamrer, Nattisa Niyomtham, Chayutra Chaiwut, Charoen Posa, Nuttapon Apiratikul, Ek Sangvichien, Praneet Opanasopit, Uthai Sakee, Boon-ek Yingyongnarongkul, Widchaya Radchatawedchakoon
Format: Article
Language:English
Published: Prince of Songkla University 2020-02-01
Series:Songklanakarin Journal of Science and Technology (SJST)
Subjects:
cationic lipid
cholesterol
serum compatibility
tetramethylguanidinium headgroup
transfection
Online Access:https://rdo.psu.ac.th/sjstweb/journal/42-1/28.pdf

Internet

https://rdo.psu.ac.th/sjstweb/journal/42-1/28.pdf

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