New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.

New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.

BACKGROUND: Oxidative damage to DNA, if not repaired, can be both miscoding and blocking. These genetic alterations can lead to mutations and/or cell death, which in turn cause cancer and aging. Oxidized DNA bases are substrates for two overlapping repair pathways: base excision (BER) and nucleotide...

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Bibliographic Details
Main Authors: Modesto Redrejo-Rodríguez, Christine Saint-Pierre, Sophie Couve, Abdelghani Mazouzi, Alexander A Ishchenko, Didier Gasparutto, Murat Saparbaev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3143120?pdf=render

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http://europepmc.org/articles/PMC3143120?pdf=render

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