LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo

LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo

Abstract Background Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment is one of the most daunting challenges in oncology. The blood–brain barrier (BBB) is the main obstacle that prevents the delivery of potentially active therapeutic compounds. In this s...

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Bibliographic Details
Main Authors: Chen He, Zhiyuan Zhang, Yinan Ding, Kangli Xue, Xihui Wang, Rui Yang, Yanli An, Dongfang Liu, Chunmei Hu, Qiusha Tang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Nanobiotechnology
Subjects:
pH-sensitive
Polymersomes
Glioblastoma
Brain-targeting
Combination therapy
Online Access:https://doi.org/10.1186/s12951-020-00751-x

Internet

https://doi.org/10.1186/s12951-020-00751-x

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